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Flavonoids do not exhibit sufficient activity to be used for chemotherapy, however they can be chemically modified by complexation with metals such as copper (Cu) (II) for instance, in order to be applied for adjuvant therapy. This study investigated the effects of Cu(II) and 2,2′-bipyridine complexation with naringenin on MDA-MB-231 cells. We demonstrated that naringenin complexed with Cu(II) and 2,2′-bipyridine (NGENCuB) was more efficient inhibiting colony formation, proliferation and migration of MDA-MB-231 tumor cells, than naringenin (NGEN) itself.
2,2′-Bipyridine (bipy or bpy, pronounced ) is an organic compound with the formula C10H8N2. This colorless solid is an important isomer of the bipyridine family. It is a bidentate chelating ligand, forming complexes with many transition metals. Ruthenium complex and platinum complexes of bipy exhibit intense luminescence, which may have practical applications.
Synthesis of New Chiral 2,2-Bipyridyl-Type Ligands, Their Coordination to Molybdenum(0), Copper(II), and Palladium(II), and Application in Asymmetric Allylic Substitution, Allylic Oxidation, and Cyclopropanation
Chemical reagents are affected by external factors such as temperature, light irradiation, air and moisture during storage, transportation and sales, and are prone to physical chemistry such as deliquescence,mycin, discoloration, polymerization, oxidation, volatilization, sublimation and decomposition. Change, make it invalid and unusable.
Inorganic compounds can be used for a long time as long as they are properly stored and packaged intact. However, those substances that are easily oxidized and deliquescent can be stored in a short period of time (1 to 5 years) in the dark, shade, and dry conditions, depending on whether the packaging and storage conditions are in compliance.
parallels between the coordination chemistries of the bidentate ligands 2,2-bipyridine (bpy) and 1,10-phenanthroline (phen)
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