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Zhangjiagang Clent Chemical Co., Ltd. has cultivated a large international market, especially in the aspect of fine organic chemicals, including: curatorial materials, intermediates and organic chemical intermediates. We have made great efforts in production efficiency improvement, management system establishment, quality control and systemic service providing.

Copper (II) and 2,2-Bipyridine Complexation Improves Chemopreventive Effects

Flavonoids do not exhibit sufficient activity to be used for chemotherapy, however they can be chemically modified by complexation with metals such as copper (Cu) (II) for instance, in order to be applied for adjuvant therapy. This study investigated the effects of Cu(II) and 2,2′-bipyridine complexation with naringenin on MDA-MB-231 cells. We demonstrated that naringenin complexed with Cu(II) and 2,2′-bipyridine (NGENCuB) was more efficient inhibiting colony formation, proliferation and migration of MDA-MB-231 tumor cells, than naringenin (NGEN) itself.

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2,2-Bipyridyl an organic compound parameters

2,2′-Bipyridine (bipy or bpy, pronounced ) is an organic compound with the formula C10H8N2. This colorless solid is an important isomer of the bipyridine family. It is a bidentate chelating ligand, forming complexes with many transition metals. Ruthenium complex and platinum complexes of bipy exhibit intense luminescence, which may have practical applications.

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